Where are plasmacytoid dendritic cells?

Where are plasmacytoid dendritic cells?

Plasmacytoid dendritic cells (pDCs) are a rare type of immune cell that are known to secrete large quantities of type 1 interferon (IFNs) in response to a viral infection. They circulate in the blood and are found in peripheral lymphoid organs.

What activates plasmacytoid dendritic cells?

Plasmacytoid dendritic cells (pDC) are activated indirectly or directly by immune complexes and secrete high amounts of type I interferon in a TLR7 and/or 9-dependent mechanism.

Do pDCs activate lymphocytes?

All three E proteins bind to the same consensus sequence and share target genes; accordingly, TCF4 in pDCs binds to and activates many genes that are activated by E2A/HEB in developing lymphocytes (Ceribelli et al., 2016; Ghosh et al., 2014).

What are plasmacytoid lymphoid cells?

Plasmacytoid dendritic cells (pDCs) resemble antibody-secreting plasma cells and are believed to arise from a lymphoid progenitor. pDCs are found in blood and in lymphoid tissues such as lymph nodes, tonsils, spleen, thymus, and Peyer’s patches. Activated pDCs link innate immunity and adaptive immunity to viruses.

Are plasmacytoid dendritic cells innate?

The many fates of pDCs. pDCs play a central role in immunity, not restricted to their capacity to secrete IFN-α/β in response to viruses and induce an antiviral innate immune response.

What do plasmacytoid dendritic cells release?

Plasmacytoid dendritic cells (pDCs) are a specific subset of naturally occurring dendritic cells, that secrete large amounts of Type I interferon and play an important role in the immune response against viral infection.

Where are plasmacytoid cells found?

Plasmacytoid Dendritic Cells pDCs are found in blood and in lymphoid tissues such as lymph nodes, tonsils, spleen, thymus, and Peyer’s patches.

Are plasmacytoid dendritic cells myeloid cells?

DCs are classified as myeloid DCs and plasmacytoid DCs (134,135). Myeloid DCs are responsible for presenting antigens to T cells. In contrast to myeloid DCs, pDCs are a rare subset of DCs. pDCs contribute to antiviral immunity through their ability to produce high levels of IFN-alpha upon activation.

Are plasmacytoid dendritic cells antigen presentation?

One of the remaining enigmas of the dendritic cell (DC) network is the potential contribution of plasmacytoid DCs (pDCs) to antigen presentation. Instead, pDCs are regarded as immunomodulating cells, capable of directing the immune response through their secretion of large amounts of type I interferons.