What is the chemical structure of lidocaine?
Lidocaine hydrochloride
| PubChem CID | 6314 |
|---|---|
| Structure | Find Similar Structures |
| Chemical Safety | Laboratory Chemical Safety Summary (LCSS) Datasheet |
| Molecular Formula | C14H23ClN2O |
| Synonyms | Lidocaine hydrochloride 73-78-9 LIDOCAINE HCL Lidothesin Xyloneural More… |
What is lidocaine made of?
lidocaine, synthetic organic compound used in medicine, usually in the form of its hydrochloride salt, as a local anesthetic. Lidocaine produces prompter, more intense, and longer lasting anesthesia than does procaine (Novocaine).
How do you make lidocaine?
1. Dissolve the lidocaine in ether (10 mL per gram of lidocaine) and add 2 mL of 2.2 M sulfuric acid in ethanol per gram of lidocaine. 2. Stir and scratch with a glass rod to mix and induce crystallization.
What is the Iupac name of lidocaine?
Lidocaine, also known as lignocaine and sold under the brand name Xylocaine among others, is a local anesthetic of the amino amide type….Lidocaine.
| Clinical data | |
|---|---|
| show IUPAC name | |
| CAS Number | 137-58-6 as HCl: 73-78-9 |
| PubChem CID | 3676 as HCl: 6314 |
| IUPHAR/BPS | 2623 |
Is lidocaine basic or acidic?
Lidocaine with epinephrine is very acidic compared with subcutaneous tissue. The addition of 8.4% bicarbonate at a volume ratio of 1 mL:10 mL neutralizes the acidity of 1% lidocaine with 1:100,000 epinephrine. Neutralizing the pH of lidocaine has been previously shown to decrease the pain of injection.
Is lidocaine plant based?
In summary, The Vegan Society states that being vegan should be “as far as is possible and practicable”6….
| Drug group | Examples | Use |
|---|---|---|
| Local anaesthetics | Lignocaine, bupivacaine, ropivacaine | To numb small areas for minor surgery or to block nerves and numb body regions |
What is lidocaine metabolite?
It has been shown that the antiarrhythmic and toxic effects of lidocaine may be in part dependent on its two active metabolites, monoethylglycylxylidide (MEGX) and glycylxylidide (GX).
Is lidocaine metabolized by the kidney?
While lidocaine pharmacokinetics are not significantly altered in CKD, its clearance has been shown to be reduced in proportion to the degree of impairment in kidney function in patients not receiving hemodialysis [17].
Is lidocaine hydrophilic or hydrophobic?
As a tertiary amine, lidocaine can be hydrophilic when it is protonated and can be hydrophobic when it is in its neutral form. If lidocaine is made permanently charged, such as its derivative QX-314 (F1-20), the compound becomes inactive when applied externally.
What is the molecular formula for lidocaine hydrochloride?
Lidocaine hydrochloride PubChem CID 6314 Structure Find Similar Structures Chemical Safety Laboratory Chemical Safety Summary (LCSS Molecular Formula C14H23ClN2O Synonyms Lidocaine hydrochloride 73-78-9 LIDOCAIN
What is the physiological pH of lidocaine?
As a result, about 25% of lidocaine molecules will be un-ionized and available at the physiological pH of 7.4 to translocate inside nerve cells, which means lidocaine elicits an onset of action more rapidly than other local anesthetics that have higher pKa values.
What is the dissociation constant of lidocaine?
Moreover, lidocaine possesses a dissociation constant (pKa) of 7.7 and is considered a weak base.
What is the pKa of lidocaine?
The estimated pKa of lidocaine is 7.75 (3), indicating that this compound will exist partially in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts (4). (1) US EPA; Estimation Program Interface (EPI) Suite.