What is Micronodular cirrhosis?
Micronodular cirrhosis corresponds to liver parenchyma in which almost all nodules are smaller than 3 mm. This is the classical “Laennec cirrhosis” caused by chronic alcohol-induced liver injury (Fig. 41.1A) but which is also seen in hemochromatosis, chronic biliary disorders (Fig. 41.1B), and Wilson disease.
What is the difference between Micronodular and Macronodular cirrhosis?
In the micronodular form (Laennec’s cirrhosis or portal cirrhosis), regenerating nodules are under 3 mm. In macronodular cirrhosis (post-necrotic cirrhosis), the nodules are larger than 3 mm.
How does cirrhosis cause Hyperestrogenism?
The instantaneous contribution of plasma androstenedione to estrone and estradiol was increased in cirrhosis as was the contribution of testosterone to estrone (but not to estradiol). Thus the increased estradiol levels in cirrhosis result, in large part, from increased peripheral conversion from the androgens.
What is Micronodular contour of liver?
Micronodular cirrhosis is characterized by regenerative nodules of relatively uniform and small size. This pattern is seen in chronic alcoholic, hepatitis C, and biliary cirrhosis. In macronodular cirrhosis, the parenchymal nodules are larger, and more variable in size.
What stage of cirrhosis does edema occur?
Stage 3 cirrhosis involves the development of swelling in the abdomen and advanced liver scarring. This stage marks decompensated cirrhosis, with serious complications and possible liver failure.
What causes hyperestrogenism?
Hyperestrogenism can be caused by ovarian tumors, genetic conditions such as aromatase excess syndrome (also known as familial hyperestrogenism), or overconsumption of exogenous sources of estrogen, including medications used in hormone replacement therapy and hormonal contraception.
What is hyperestrogenism?
Hyperestrogenism includes clinical signs of prolonged estrus, anestrus, infertility, delayed return to estrus, increased mammary or udder development and abnormal lactation, swollen external genitalia, and atrophy of ovaries or testicles.
What is the caudate lobe of liver?
The caudate lobe represents the only part of the liver that is in contact with the vena cava, except at the entrance of the main hepatic veins into the vena cava, and provides an anastomosis between the hepatic veins and vena cava.
What are the causes of micronodular cirrhosis?
Common causes of micronodular cirrhosis include chronic alcohol usage, hemochromatosis, biliary tract obstruction, chronic venous flow obstruction, and childhood metabolic diseases, and one of the rare causes is cirrhosis secondary to chronic active hepatitis.
What is micronodular cirrhosis (c0267812)?
Micronodular cirrhosis (Concept Id: C0267812) A type of cirrhosis characterized by the presence of small regenerative nodules. Micronodular cirrhosis MedGen UID: 75640 •Concept ID: C0267812 Disease or Syndrome SNOMED CT: Micronodular cirrhosis (21861000) HPO: HP:0001413 Definition
What are the morphological changes in cirrhosis of the liver?
micronodular cirrhosis morphological changes in the liver resulting in an enlarged liver. mixed cirrhosis morphological changes in the diseased liver that represent both the micronodular and macronodular patterns.
What is macronodular cirrhosis?
macronodular cirrhosis morphological changes that cause the liver to become small and shrunken. metabolic cirrhosis cirrhosis associated with metabolic diseases such as hemochromatosis, wilson’s disease, glycogen storage disease, galactosemia, and disorders of amino acid metabolism.